Patients who do not achieve a CR or CRi within 3 cycles should discontinue treatment. Subsequent cycles are 4 weeks in duration. In patients who do not achieve a CR or CRi, the recommended total dose of BESPONSA is 1.8 mg/m 2 per cycle given as 3 divided doses on Day 1 (0.8 mg/m 2), Day 8 (0.5 mg/m 2), and Day 15 (0.5 mg/m 2).In patients who achieve a CR or CRi, the recommended total dose of BESPONSA is 1.5 mg/m 2 per cycle, administered as 3 divided doses on Day 1 (0.5 mg/m 2), Day 8 (0.5 mg/m 2), and Day 15 (0.5 mg/m 2).Cycle 1 is 3 weeks in duration, but may be extended to 4 weeks if the patient achieves a complete remission (CR) or complete remission with incomplete hematologic recovery (CRi), and/or to allow recovery from toxicity. ![]() ![]() For the first cycle, the recommended total dose of BESPONSA for all patients is 1.8 mg/m 2 per cycle, administered as 3 divided doses on Day 1 (0.8 mg/m 2), Day 8 (0.5 mg/m 2), and Day 15 (0.5 mg/m 2).
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